Calculo B Diva Flemming Exercicios Resolvidos Download Pdf
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Atrial natriuretic peptide levels in the ascitic fluid of patients with cirrhosis of the liver: its pathophysiological and clinical significance.
The intravenous injection of synthetic atrial natriuretic peptide (ANP) to patients with cirrhosis of the liver produces a rapid fall in arterial blood pressure and a marked reduction of total peripheral vascular resistance. To elucidate the mechanism of this vasodepressor effect of ANP, the plasma levels of this peptide, ANP-like immunoreactivity, atrial natriuretic factor (ANF) and ANF-like immunoreactivity (ANF-LI) were studied in the ascitic fluid of 17 patients with cirrhosis of the liver, using a radioimmunoassay. The plasma ANP level was elevated in all patients (10.4 +/- 2.6 ng/ml) in comparison with the age-matched healthy control subjects (5.1 +/- 0.8 ng/ml). No differences were detected in ANP-LI levels between these groups, although ANP-LI levels in the ascitic fluid were markedly elevated in the patients with cirrhosis (38.7 +/- 11.8 ng/ml). ANF levels in the ascitic fluid were significantly higher in the patients than in the healthy subjects (334.3 +/- 19.4 pg/ml versus 274.8 +/- 19.4 pg/ml, respectively). ANF levels were significantly correlated to the serum ANP levels (r = 0.67, p less than 0.001). These results strongly suggest that ANP acts as a potent vasodilator in patients with cirrhosis of the liver, and ANF in the ascitic fluid may be responsible for the vasodepressor effect of ANP.Q:
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May 30, 2019
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